Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus-Reference-Cited by-同舟云学术

Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hehnly Christine¹,Shi Aiqin¹,Ssentongo Paddy²³,Zhang Lijun⁴,Isaacs Albert⁵,Morton Sarah U.⁶,Streck Nicholas⁷,Erdmann-Gilmore Petra⁸,Tolstoy Igor⁹,Townsend R. Reid⁸,Limbrick David D.¹⁰,Paulson Joseph N.¹,Ericson Jessica E.¹¹,Galperin Michael Y.⁹^ORCID,Schiff Steven J.¹²,Broach James R.¹^ORCID

Affiliation:

1. Institute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

2. Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

3. Department of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA

4. Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

5. Division of Neurosurgery, Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada

6. Division of Newborn Medicine, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

7. Department of Pathology and Laboratory Medicine Division of Clinical Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

8. Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

9. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA

10. Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA

11. Division of Pediatric Infectious Disease, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

12. Department of Neurosurgery, Yale University, New Haven, Connecticut, USA

Abstract

Postinfectious hydrocephalus, a devastating sequela of neonatal infection, is associated with increased childhood mortality and morbidity. A novel bacterial pathogen, Paenibacillus thiaminolyticus , is highly associated with postinfectious hydrocephalus in an African cohort.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

PSU | Penn State College of Medicine

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02688-22

Reference102 articles.

1. Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis

2. Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance

3. Hydrocephalus in Uganda: the predominance of infectious origin and primary management with endoscopic third ventriculostomy

4. Pediatric Hydrocephalus in East Africa: Prevalence, Causes, Treatments, and Strategies for the Future

5. Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda

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1. Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study;The Lancet Microbe;2023-08

2. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda;Clinical Infectious Diseases;2023-06-05