Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier-Reference-Cited by-同舟云学术

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Shrestha Neeta¹,Gall Flavio Max²^ORCID,Mathieu Cyrille³^ORCID,Hierweger Melanie Michaela¹,Brügger Melanie⁴⁵⁶,Alves Marco P.⁴⁵,Vesin Jonathan⁷,Banfi Damiano⁷,Kalbermatter David⁸,Horvat Branka³^ORCID,Chambon Marc⁷,Turcatti Gerardo⁷,Fotiadis Dimitrios⁸,Riedl Rainer²^ORCID,Plattet Philippe¹^ORCID

Affiliation:

1. Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland

2. Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Wädenswil, Switzerland

3. CIRI, Centre International de Recherche en Infectiologie, Team Immunobiology of the Viral Infections, Univ Lyon, INSERM, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France

4. Institute of Virology and Immunology, Bern, Switzerland

5. Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

6. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

7. Biomolecular Screening Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

8. Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland

Abstract

Measles virus, respiratory syncytial virus, canine distemper virus, and Nipah virus are some of the clinically significant RNA viruses that threaten substantial number of lives each year. Limited to no availability of treatment options for these viral infections makes it arduous to handle the outbreaks.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02621-21

Reference50 articles.

1. A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals

2. Paramyxovirus circulation in bat species from French Guiana

3. Combating vaccine hesitancy and other 21st century social determinants in the global fight against measles

4. World Health Organization. 2020. Worldwide measles deaths climb 50% from 2016 to 2019 claiming over 207 500 lives in 2019. World Health Organization Geneva Switzerland. https://www.who.int/news/item/12-11-2020-worldwide-measles-deaths-climb-50-from-2016-to-2019-claiming-over-207-500-lives-in-2019.

5. EVALUATION OF TWO CANINE DISTEMPER VIRUS VACCINES IN CAPTIVE TIGERS (PANTHERA TIGRIS)

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immunopathogenesis of Nipah Virus Infection and Associated Immune Responses;Immuno;2023-04-27

2. LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus;mBio;2023-02-28

3. Selective SLAM/CD150 receptor-detargeting of canine distemper virus;Virus Research;2022-09

4. Persistent Infection of a Canine Histiocytic Sarcoma Cell Line with Attenuated Canine Distemper Virus Expressing Vasostatin or Granulocyte-Macrophage Colony-Stimulating Factor;International Journal of Molecular Sciences;2022-05-31

5. Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds;Viruses;2022-05-29