A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols-Reference-Cited by-同舟云学术

A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lu Hui¹^ORCID,Li Wanqian¹,Whiteway Malcolm²,Wang Hongkang³,Zhu Shuo¹,Ji Zhe¹,Feng Yanru¹,Yan Lan⁴,Fang Ting¹,Li Liping¹,Ni Tingjunhong¹,Zhang Xiaolong⁴,Lv Quanzhen⁴,Ding Zichao⁴,Qiu Lijuan⁴,Zhang Dazhi¹⁴,Jiang Yuanying¹

Affiliation:

1. Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China

2. Department of Biology, Concordia University, Montreal, Quebec, Canada

3. Department of Physiology and Pharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

4. School of Pharmacy, Naval Medical University, Shanghai, China

Abstract

Fluconazole (FLC) tolerance increases the frequency of acquired FLC resistance, and a high FLC tolerance level is associated with persistent candidemia. Multiple functional proteins, such as calcineurin, heat shock protein 90 (Hsp90), and ADP ribosylation factor, are essential for the survival of C. albicans exposed to FLC, but how these factors increase the fungicidal activity of FLC remains to be determined.

Funder

Innovation Program of Shanghai Municipal Education Commission

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02639-22

Reference68 articles.

1. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America