Attachment of Enterohemorrhagic Escherichia coli to Host Cells Reduces O Antigen Chain Length at the Infection Site That Promotes Infection-Reference-Cited by-同舟云学术

Attachment of Enterohemorrhagic Escherichia coli to Host Cells Reduces O Antigen Chain Length at the Infection Site That Promotes Infection

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Liu Bin¹²³⁴,Qian Chengqian¹,Wu Pan¹,Li Xiaodan¹,Liu Yutao¹,Mu Huiqian¹,Huang Min¹,Zhang Yang¹,Jia Tianyuan¹,Wang Yuanyuan¹,Wang Lu¹,Zhang Xiao¹,Huang Di¹,Yang Bin¹^ORCID,Feng Lu¹³⁴,Wang Lei¹²³⁴⁵

Affiliation:

1. TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, People’s Republic of China

2. The Institute of Translational Medicine Research, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Nankai University, Tianjin, People’s Republic of China

3. The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin, People’s Republic of China

4. Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin, People’s Republic of China

5. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, People’s Republic of China

Abstract

Little is known about the regulation of cell wall structure of enteropathogenic bacteria within the host. Here, we report that enterohemorrhagic Escherichia coli regulates its cell wall structure during the infection process, which balances its survival in the intestinal lumen and infection of intestinal epithelial cells.

Funder

National Natural Science Foundation of China

National Key Programs for Infectious Diseases of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02692-21

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