Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation

Author:

de Assis Leandro José1ORCID,Bain Judith M.2,Liddle Corin3,Leaves Ian1,Hacker Christian3,Peres da Silva Roberta1,Yuecel Raif4,Bebes Attila4,Stead David5,Childers Delma S.2,Pradhan Arnab1,Mackenzie Kevin2,Lagree Katherine6,Larcombe Daniel E.1,Ma Qinxi1,Avelar Gabriela Mol2,Netea Mihai G.789,Erwig Lars P.210,Mitchell Aaron P.6ORCID,Brown Gordon D.1,Gow Neil A. R.1ORCID,Brown Alistair J. P.1ORCID

Affiliation:

1. Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom

2. Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

3. Bioimaging Unit, University of Exeter, Exeter, United Kingdom

4. Exeter Centre for Cytomics, University of Exeter, Exeter, United Kingdom

5. Aberdeen Proteomics Facility, Rowett Institute, University of Aberdeen, Aberdeen, United Kingdom

6. Department of Microbiology, University of Georgia, Athens, Georgia, USA

7. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands

8. Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands

9. Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany

10. Johnson-Johnson Innovation, EMEA Innovation Centre, London, United Kingdom

Abstract

Microbes that coexist with humans have evolved ways of avoiding or evading our immunological defenses. These include the masking by these microbes of their “pathogen-associated molecular patterns” (PAMPs), which are recognized as “foreign” and used to activate protective immunity.

Funder

UKRI | Medical Research Council

Wellcome Trust

EC | European Research Council

ZonMw

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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