The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 / UL5 Transcripts-Reference-Cited by-同舟云学术

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 / UL5 Transcripts

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Gonzalez-Perez Ana Cristina¹^ORCID,Stempel Markus¹²^ORCID,Wyler Emanuel³,Urban Christian⁴,Piras Antonio⁴,Hennig Thomas⁵⁶^ORCID,Ganskih Sabina⁶,Wei Yuanjie⁶,Heim Albert⁷^ORCID,Landthaler Markus³⁸,Pichlmair Andreas⁴,Dölken Lars⁵⁶,Munschauer Mathias⁶,Erhard Florian⁵,Brinkmann Melanie M.¹²^ORCID

Affiliation:

1. Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany

2. Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany

3. Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

4. School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany

5. Institute for Virology and Immunobiology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany

6. Helmholtz-Institute for RNA-based Infection Research, HIRI, Würzburg, Germany

7. Institute of Virology, Hannover Medical School, Hannover, Germany

8. IRI Life Sciences, Institute of Biology, Humboldt-Universität Berlin, Berlin, Germany

Abstract

Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often accompanied by the occurrence of resistant mutants.

Funder

European Union Horizon 2020

Deutsche Forschungsgemeinschaft

Ministry of Science and Culture, Lower Saxony, Germany

Helmholtz Association

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02683-20

Reference86 articles.