Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease-Reference-Cited by-同舟云学术

Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Driuchina Anastasiia¹,Hintikka Jukka¹,Lehtonen Marko²,Keski-Rahkonen Pekka³,O’Connell Thomas⁴,Juvonen Risto²,Kuula Juho⁵⁶,Hakkarainen Antti⁵⁶,Laukkanen Jari A.⁷⁸,Mäkinen Elina¹,Lensu Sanna¹⁹,Pietiläinen Kirsi H.¹⁰¹¹,Pekkala Satu¹¹²^ORCID

Affiliation:

1. Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland

2. Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

3. Nutrition and Metabolism Branch, International Agency for Cancer on Research, Lyon, France

4. Indiana University School of Medicine, Indianapolis, Indiana, USA

5. HUS Medical Imaging Center, Department of Radiology, University of Helsinki, Helsinki, Finland

6. Helsinki University Hospital, Population Health Research, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland

7. Department of Medicine, Central Finland Health Care District, Jyväskylä, Finland

8. Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland

9. Faculty of Education and Psychology, University of Jyväskylä, Jyväskylä, Finland

10. Obesity Research Unit, Research Program for Clinical and Molecular Medicine, Faculty of Medicine, University of Helsinki, Helsinki, Finland

11. HealthyWeightHub, Abdominal Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

12. Department of Clinical Microbiology, Turku University Hospital, Turku, Finland

Abstract

Because the high prevalence of nonalcoholic fatty liver disease sets diagnostic challenges to health care, identification of new biomarkers of the disease that in the future could have potential utility as diagnostic biomarkers of high liver fat content is important. Our results show that increased amino acid degradation products in the feces may be such biomarkers.

Funder

Academy of Finland

Novo Nordisk Fonden

Diabetestutkimussäätiö

Helsingin Yliopisto

Helsinki University Hospital Government Research Funds

Finnish Cultural Foundation

Signe ja Ane Gyllenbergin Säätiö

Suomen Lääketieteen Säätiö

Varsinais-Suomen Sairaanhoitopiiri

WRI | Jenny ja Antti Wihurin Rahasto

Academy of Finland | Faculty of Sport and Health Sciences/ University of Jyväskylä