Salmonella strain secreting active listeriolysin changes its intracellular localization-Reference-Cited by-同舟云学术

Salmonella strain secreting active listeriolysin changes its intracellular localization

Published:1995-10 Issue:10 Volume:63 Page:4202-4205
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Gentschev I¹,Sokolovic Z¹,Mollenkopf H J¹,Hess J¹,Kaufmann S H¹,Kuhn M¹,Krohne G F¹,Goebel W¹

Affiliation:

1. Lehrstuhl für Mikrobiologie, Theodor-Boveri-Institut für Biowissenschaften, Würzburg, Germany.

Abstract

We describe the construction of an attenuated Salmonella dublin aroA strain which secretes via the Escherichia coli hemolysin secretion machinery an active hybrid cytolysin consisting of listeriolysin from Listeria monocytogenes and the C-terminal secretion signal of E. coli hemolysin. This hemolytic S. dublin strain is partially released into the cytoplasm of the host cell following uptake by J774 macrophage cells, whereas the nonhemolytic control S. dublin aroA strain remains in the phagosome.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.63.10.4202-4205.1995

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