Thymidine-Dependent Staphylococcus aureus Small-Colony Variants: Human Pathogens That Are Relevant Not Only in Cases of Cystic Fibrosis Lung Disease-Reference-Cited by-同舟云学术

Thymidine-Dependent Staphylococcus aureus Small-Colony Variants: Human Pathogens That Are Relevant Not Only in Cases of Cystic Fibrosis Lung Disease

Published:2008-11 Issue:11 Volume:46 Page:3829-3832
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Besier Silke¹,Zander Johannes¹,Siegel Ekkehard²,Saum Stephan H.³,Hunfeld Klaus-Peter¹,Ehrhart Annabelle¹,Brade Volker¹,Wichelhaus Thomas A.¹

Affiliation:

1. Institute of Medical Microbiology and Infection Control, Hospital of Johann Wolfgang Goethe-University, Frankfurt/Main, Germany

2. Institute of Medical Microbiology, Hospital of Johannes Gutenberg-University, Mainz, Germany

3. Institute of Molecular Biosciences, University, Frankfurt/Main, Germany

Abstract

ABSTRACT We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia. Furthermore, we provide evidence that the essential growth factor for TD-SCVs, i.e., thymidine, and its metabolite dTMP are present in various human specimens.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01440-08

Reference24 articles.

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2. Prevalence and Clinical Significance of Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Lung Disease

3. The Thymidine-Dependent Small-Colony-Variant Phenotype Is Associated with Hypermutability and Antibiotic Resistance in Clinical Staphylococcus aureus Isolates

4. In Vivo Mutations of Thymidylate Synthase (Encoded by thyA ) Are Responsible for Thymidine Dependency in Clinical Small-Colony Variants of Staphylococcus aureus

5. formance standards for antimicrobial susceptibility testing; 18th informational supplement 2008 vol. 28

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