Impact of Rapid Antimicrobial Susceptibility Testing in Gram-Negative Rod Bacteremia: a Quasi-experimental Study-Reference-Cited by-同舟云学术

Impact of Rapid Antimicrobial Susceptibility Testing in Gram-Negative Rod Bacteremia: a Quasi-experimental Study

Published:2020-08-24 Issue:9 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Hogan Catherine Anne¹²,Ebunji Bertrand²,Watz Nancy²,Kapphahn Kristopher³,Rigdon Joseph³,Mui Emily⁴,Meng Lina⁴,Alegria William⁴,Holubar Marisa⁴⁵,Deresinski Stanley⁴⁵,Banaei Niaz¹²⁵

Affiliation:

1. Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

2. Clinical Microbiology Laboratory, Stanford Health Care, Palo Alto, California, USA

3. Quantitative Sciences Unit, Stanford University, Stanford, California, USA

4. Department of Quality, Patient Safety and Effectiveness, Stanford University School of Medicine, Stanford, California, USA

5. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

Abstract

Clinical justification for rapid antimicrobial susceptibility testing (AST) in Gram-negative rod (GNR) bacteremia is compelling; however, evidence supporting its value is sparse. We investigated the impact of rapid AST on clinical and antimicrobial stewardship outcomes in real-world practice. We performed a before-and-after quasi-experimental study from February 2018 to July 2019 at a tertiary hospital of the 24-h/day, 7-day/week implementation of the direct Vitek 2 AST method from positive blood culture broth for GNR bacteremia with electronic isolate-specific de-escalation comments and daytime antibiotic stewardship program (ASP) intervention.

Funder

Stanford Department of Pathology

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00360-20

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