Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18

Author:

Chen Xiangpeng1ORCID,Qu Xiao2,Liu Congcong34,Zhang Yong56,Zhang Guigen7,Han Pu2,Duan Yali1,Li Qi1,Wang Liang2,Ruan Wenjing28,Wang Peiyi4,Wei Wensheng9,Gao George F.2ORCID,Zhao Xin210,Xie Zhengde1ORCID

Affiliation:

1. Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

2. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

3. Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen, China

4. Cryo-EM Centre, Department of Biology, Southern University of Science and Technology, Shenzhen, China

5. National Laboratory for Poliomyelitis, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

6. Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

7. Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China

8. Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

9. Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China

10. CAS Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China

Abstract

E18 is a member of enterovirus species B. As one of the most common enterovirus serotypes in nonpolio enterovirus detection, it easily infects children and causes various clinical symptoms.

Funder

National Natural Science Foundation of China

Beijing Nova Program of Science and Technology

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Natural Science Foundation of Beijing Municipality

CAMS Innovation Fund for Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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