The Gut Bacterial Community Potentiates Clostridioides difficile Infection Severity-Reference-Cited by-同舟云学术

The Gut Bacterial Community Potentiates Clostridioides difficile Infection Severity

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lesniak Nicholas A.¹,Schubert Alyxandria M.¹,Flynn Kaitlin J.¹,Leslie Jhansi L.¹,Sinani Hamide¹,Bergin Ingrid L.²,Young Vincent B.¹³^ORCID,Schloss Patrick D.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

2. Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA

3. Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

Abstract

Clostridioides difficile colonization can be asymptomatic or develop into an infection ranging in severity from mild diarrhea to toxic megacolon, sepsis, and death. Models that predict severity and guide treatment decisions are based on clinical factors and C. difficile characteristics.

Funder

National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01183-22

Reference88 articles.

1. Clostridium difficile— More Difficult Than Ever

2. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

3. External Validation and Comparison of Clostridioides difficile Severity Scoring Systems