Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent

Author:

Steinig Eike J.12,Duchene Sebastian3,Robinson D. Ashley4,Monecke Stefan567,Yokoyama Maho8,Laabei Maisem8,Slickers Peter56,Andersson Patiyan1,Williamson Deborah910ORCID,Kearns Angela11,Goering Richard V.12,Dickson Elizabeth13,Ehricht Ralf57,Ip Margaret14ORCID,O’Sullivan Matthew V. N.15,Coombs Geoffrey W.16,Petersen Andreas17,Brennan Grainne18,Shore Anna C.19ORCID,Coleman David C.19ORCID,Pantosti Annalisa20,de Lencastre Herminia2122,Westh Henrik2324,Kobayashi Nobumichi25,Heffernan Helen26,Strommenger Birgit27,Layer Franziska27,Weber Stefan28,Aamot Hege Vangstein29,Skakni Leila30,Peacock Sharon J.31,Sarovich Derek132,Harris Simon33,Parkhill Julian34ORCID,Massey Ruth C.35ORCID,Holden Mathew T. G.3336ORCID,Bentley Stephen D.33,Tong Steven Y. C.137ORCID

Affiliation:

1. Menzies School of Health Research, Darwin, Australia

2. Australian Institute of Tropical Health and Medicine, Townsville, Australia

3. Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

4. University of Mississippi Medical Center, Jackson, Mississippi, USA

5. Leibniz Institute of Photonic Technology (IPHT), Jena, Germany

6. InfectoGnostics Research Campus, Jena, Germany

7. Technical University of Dresden, Dresden, Germany

8. Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

9. Doherty Applied Microbial Genomics, Department of Microbiology & Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

10. Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

11. Public Health England, National Infection Service, London, United Kingdom

12. Creighton University, Omaha, Nebraska, USA

13. Scottish Microbiology Reference Laboratories, Glasgow, United Kingdom

14. The Chinese University of Hong Kong, Hong Kong

15. Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia, and New Wales Health Pathology, Westmead Hospital, Sydney, Australia

16. School of Veterinary and Laboratory Sciences, Murdoch University, Murdoch, Australia

17. Statens Serum Institut, Copenhagen, Denmark

18. National MRSA Reference Laboratory, St. James’s Hospital, Dublin, Ireland

19. Microbiology Research Unit, School of Dental Science, University of Dublin, Trinity College Dublin, Dublin, Ireland

20. Istituto Superiore di Sanità, Rome, Italy

21. Instituto de Tecnologia Química e Biológica, Oeiras, Portugal

22. The Rockefeller University, New York, New York, USA

23. University of Copenhagen, Copenhagen, Denmark

24. Hvidovre University Hospital, Hvidovre, Denmark

25. Sapporo Medical University, Sapporo, Japan

26. Institute of Environmental Science and Research, Wellington, New Zealand

27. Robert Koch Institute, Wernigerode, Germany

28. Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates

29. Akershus University Hospital, Lørenskog, Norway

30. King Fahd Medical City, Riyadh, Kingdom of Saudi Arabia

31. London School of Hygiene and Tropical Medicine, London, United Kingdom

32. Sunshine Coast University, Sippy Downs, Australia

33. Wellcome Sanger Institute, Cambridge, United Kingdom

34. Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

35. School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

36. University of St. Andrews, St. Andrews, United Kingdom

37. Victorian Infectious Disease Service, The Royal Melbourne Hospital, and Doherty Department, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Victoria, Australia

Abstract

The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh and India in 2004. In this study, we showed that the Bengal Bay clone emerged from a virulent progenitor circulating on the Indian subcontinent. Its subsequent global transmission was associated with travel or family contact in the region. ST772 progressively acquired specific resistance elements at limited cost to its fitness and continues to be exported globally, resulting in small-scale community and health care outbreaks. The Bengal Bay clone therefore combines the virulence potential and epidemiology of community-associated clones with the multidrug resistance of health care-associated S. aureus lineages. This study demonstrates the importance of whole-genome sequencing for the surveillance of highly antibiotic-resistant pathogens, which may emerge in the community setting of regions with poor antibiotic stewardship and rapidly spread into hospitals and communities across the world.

Funder

HHS | National Institutes of Health

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3