Affiliation:
1. School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel
Abstract
The Elg1protein forms an RFC-like complex in charge of unloading PCNA from chromatin during DNA replication and repair. Mutations in the
ELG1
gene caused genomic instability in all organisms tested and cancer in mammals. Here we show that Elg1 plays a role in the induction of the DNA damage checkpoint, a cellular response to DNA damage. We show that this defect is due to a defect in the signal amplification process during induction. Thus, cells coordinate the cell's response and the PCNA unloading through the activity of Elg1.
Funder
Israel Science Foundation
Israel Cancer Research Fund
Minerva Foundation
Publisher
American Society for Microbiology
Cited by
11 articles.
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