Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis

Author:

Piantadosi Anne123ORCID,Mukerji Shibani S.45,Ye Simon16,Leone Michael J.4,Freimark Lisa M.1,Park Daniel1,Adams Gordon12,Lemieux Jacob125,Kanjilal Sanjat257ORCID,Solomon Isaac H.57,Ahmed Asim A.58,Goldstein Robert25,Ganesh Vijay159,Ostrem Bridget45,Cummins Kaelyn C.10,Thon Jesse M.45,Kinsella Cormac M.111,Rosenberg Eric2512,Frosch Matthew P.4512,Goldberg Marcia B.25,Cho Tracey A.4513,Sabeti Pardis1251114

Affiliation:

1. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

2. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

3. Emory University School of Medicine, Atlanta, Georgia, USA

4. Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA

5. Harvard Medical School, Boston, Massachusetts, USA

6. Harvard-MIT Program of Health Sciences and Technology, Cambridge, Massachusetts, USA

7. Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

8. Department of Pediatrics, Harvard Medical School, Children’s Hospital, Boston, Massachusetts, USA

9. Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

10. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA

11. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA

12. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

13. University of Iowa, Department of Neurology, Iowa City, Iowa, USA

14. Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

Abstract

Meningitis and encephalitis are leading global causes of central nervous system (CNS) disability and mortality. Current diagnostic workflows remain inefficient, requiring costly pathogen-specific assays and sometimes invasive surgical procedures.

Funder

HHS | NIH | National Institute of Mental Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

Harvard Medical School

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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