Deacylated tRNA Accumulation Is a Trigger for Bacterial Antibiotic Persistence Independent of the Stringent Response-Reference-Cited by-同舟云学术

Deacylated tRNA Accumulation Is a Trigger for Bacterial Antibiotic Persistence Independent of the Stringent Response

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wood Whitney N.¹,Mohler Kyle²³,Rinehart Jesse²³,Ibba Michael¹⁴

Affiliation:

1. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

2. Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA

3. Systems Biology Institute, Yale University, New Haven, Connecticut, USA

4. Schmid College of Science and Technology, Chapman University, Orange, California, USA

Abstract

Bacterial antibiotic persistence is a transient physiological state wherein cells become dormant and thereby evade being killed by antibiotics. Once the antibiotic is removed, bacterial persisters are able to resuscitate and repopulate.

Funder

DOD | United States Army | RDECOM | Army Research Office

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01132-21

Reference59 articles.

1. Persister cells, dormancy and infectious disease

2. Persistent bacterial infections and persister cells

3. Definitions and guidelines for research on antibiotic persistence

4. Distinguishing between resistance, tolerance and persistence to antibiotic treatment

5. A problem of persistence: still more questions than answers?

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