CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle-Reference-Cited by-同舟云学术

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Prabhakar Apurva T.¹,James Claire D.¹,Das Dipon¹,Otoa Raymonde¹,Day Matthew²,Burgner John¹,Fontan Christian T.¹,Wang Xu¹,Glass Sarah H.³,Wieland Andreas⁴⁵,Donaldson Mary M.⁶,Bristol Molly L.¹,Li Renfeng¹⁷^ORCID,Oliver Anthony W.²,Pearl Laurence H.²,Smith Brian O.⁸,Morgan Iain M.¹⁷^ORCID

Affiliation:

1. Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA

2. Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom

3. VCU School of Dentistry, Department of Oral Diagnostic Sciences, Richmond, Virginia, USA

4. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA

5. Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

6. School of Veterinary Medicine, University of Glasgow, Bearsden, United Kingdom

7. VCU Massey Cancer Center, Richmond, Virginia, USA

8. Institute of Molecular, Cell & Systems Biology, University of Glasgow, Glasgow, United Kingdom

Abstract

Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes formation of a complex with the cellular protein TopBP1 in vitro and in vivo .

Funder

Cancer Research UK

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01163-21

Reference108 articles.

1. Papillomaviruses in the causation of human cancers — a brief historical account

2. Human papillomavirus-related oropharyngeal cancer