Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci-Reference-Cited by-同舟云学术

Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci

Published:1995-09 Issue:17 Volume:177 Page:5161-5165
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Cassels R¹,Oliva B¹,Knowles D¹

Affiliation:

1. Department of Microbial Metabolism and Biochemistry, SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth, Surrey, United Kingdom.

Abstract

The stringent response in Escherichia coli and many other organisms is regulated by the nucleotides ppGpp and pppGpp. We show here for the first time that at least six staphylococcal species also synthesize ppGpp and pppGpp upon induction of the stringent response by mupirocin. Spots corresponding to ppGpp and pppGpp on thin-layer chromatograms suggest that pppGpp is the principal regulatory nucleotide synthesized by staphylococci in response to mupirocin, rather than ppGpp as in E. coli.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.177.17.5161-5165.1995

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5. Cassels R. T. Farmer J. M. Wilson and E. Faulds. 1992. The inhibition of staphylococcal and streptococcal isoleucyl tRNA synthetase (IRS) by mupirocin abstr. A09:030. In Abstracts of the 22nd FEBS Symposium Stockholm. Elsevier Amsterdam.

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