Molecular epidemiology of OHIO-1 beta-lactamase

Author:

Kron M A1,Shlaes D M1,Currie-McCumber C1,Medeiros A A1

Affiliation:

1. Infectious Diseases Section, Cleveland Veterans Administration Medical Center, Ohio.

Abstract

A total of 31 plasmids, all bearing a gene that encodes a novel, plasmid-mediated Richmond-Sykes class III beta-lactamase designated OHIO-1 and a gene that encodes aminoglycoside 2"-adenyltransferase, have been collected from hospitals in Ohio. By using restriction endonuclease digestion and Southern hybridization, we were able to demonstrate that all these plasmids have a common genetic origin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference14 articles.

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4. Maniatis T. E. F. Fritsch and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Cold Spring Harbor N.Y.

5. Plasmid-mediated B-lactamases of gram negative bacteria: properties and distribution;Matthew M.;J. Antimicrob. Chemother.,1979

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