Vaccination Strategies for Mucosal Immune Responses

Author:

Ogra Pearay L.1,Faden Howard1,Welliver Robert C.1

Affiliation:

1. Department of Pediatrics, Division of Infectious Diseases, State University of New York at Buffalo, and Children's Hospital of Buffalo, Buffalo, New York

Abstract

SUMMARY Mucosal administration of vaccines is an important approach to the induction of appropriate immune responses to microbial and other environmental antigens in systemic sites and peripheral blood as well as in most external mucosal surfaces. The development of specific antibody- or T-cell-mediated immunologic responses and the induction of mucosally induced systemic immunologic hyporesponsiveness (oral or mucosal tolerance) depend on complex sets of immunologic events, including the nature of the antigenic stimulation of specialized lymphoid structures in the host, antigen-induced activation of different populations of regulatory T cells (Th1 versus Th2), and the expression of proinflammatory and immunoregulatory cytokines. Availability of mucosal vaccines will provide a painless approach to deliver large numbers of vaccine antigens for human immunization. Currently, an average infant will receive 20 to 25 percutaneous injections for vaccination against different childhood infections by 18 months of age. It should be possible to develop for human use effective, nonliving, recombinant, replicating, transgenic, and microbial vector- or plant-based mucosal vaccines to prevent infections. Based on the experience with many dietary antigens, it is also possible to manipulate the mucosal immune system to induce systemic tolerance against environmental, dietary, and possibly other autoantigens associated with allergic and autoimmune disorders. Mucosal immunity offers new strategies to induce protective immune responses against a variety of infectious agents. Such immunization may also provide new prophylactic or therapeutic avenues in the control of autoimmune diseases in humans.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Reference146 articles.

1. Abraham S. N. Sharon N. Ofek I. Adhesion of bacteria to mucosal surfaces Mucosal immunology 2nd ed. Ogra P. L. Mestecky J. Lamm M. E. Strober W. Bienenstock J. McGhee J. R. 1999 31 42 Academic Press New York N.Y

2. The expression of hybrid HIV:Ty virus-like particles in yeast.;Adams S. E.;Nature,1987

3. Oral salmonella: malaria circumsporozoite recombinants induce specific CD8+ cytotoxic T cells.;Aggarwal A.;J. Exp. Med.,1990

4. T cell priming versus T cell tolerance induced by synthetic peptides.;Aichele P.;J. Exp. Med.,1995

5. Antigen-driven peripheral immune tolerance: suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen.;Al-Sabbagh A.;Cell. Immunol.,1996

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