Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors-Reference-Cited by-同舟云学术

Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors

Published:2020-03-31 Issue:8 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhang Xue¹,Zhang Tingting¹,Davis John N.¹,Marzi Andrea²,Marchese Anthony M.³,Robek Michael D.³,van den Pol Anthony N.¹

Affiliation:

1. Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA

2. Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

3. Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA

Abstract

The Ebola virus glycoprotein contains a mucin-like domain which may play a role in immune evasion. Chimeric vesicular stomatitis viruses with the EBOV glycoprotein substituted for the VSV glycoprotein show greater safety and efficacy in targeting brain tumors in immunodeficient mice when the MLD was expressed within the EBOV glycoprotein than when EBOV lacked the mucin-like domain.

Funder

HHS | NIH | National Cancer Institute

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01967-19

Reference47 articles.

1. World Health Organization (WHO). 2018. Fact sheet: Ebola virus disease. www.who.int/en/news-room/fact-sheets/detail/ebola-virus-disease.

2. Covalent Modifications of the Ebola Virus Glycoprotein