Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria-Reference-Cited by-同舟云学术

Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria

Published:2015-06-01 Issue:8 Volume:59 Page:5057-5060
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Soetaert Karine,Rens Céline,Wang Xiao-Ming,De Bruyn Jacqueline,Lanéelle Marie-Antoinette,Laval Françoise,Lemassu Anne,Daffé Mamadou,Bifani Pablo,Fontaine Véronique,Lefèvre Philippe

Abstract

ABSTRACTMycobacterium tuberculosisis wrapped in complex waxes, impermeable to most antibiotics. ComparingMycobacterium bovisBCG andM. tuberculosismutants that lack phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids with wild-type strains, we observed that glycopeptides strongly inhibited PDIM-deprived mycobacteria. Vancomycin together with a drug targeting lipid synthesis inhibited multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential antituberculosis (TB) agents and might provide a new antimycobacterial drug-screening strategy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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