Affiliation:
1. Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115
Abstract
ABSTRACT
Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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1993
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