Direct activity of recombinant human lactoferrin against Helicobacter pylori

Author:

Miehlke S1,Reddy R1,Osato M S1,Ward P P1,Conneely O M1,Graham D Y1

Affiliation:

1. Department of Medicine, Veterans Affairs Medical Center, Houston, Texas, USA.

Abstract

We report the activity of recombinant human lactoferrin against Helicobacter pylori. Lactoferrin exerted a time- and dose-dependent action against 8 of the 13 clinical isolates of H. pylori tested in vitro. These results highlight a potential therapeutic use for lactoferrin against H.pylori infection.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference9 articles.

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2. Identification of the bactericidal domain of lactoferrin;Bellamy W.;Biochem. Biophys. Acta,1992

3. Role of iron in bacterial infection;Bullen J. J.;Curr. Top. Microbiol. Immunol.,1978

4. Damage of outer membrane of gram-negative bacteria by lactoferrin and transferrin;Ellison R. T. III;Infect. Immun.,1988

5. Helicobacter pylori: current status;Graham D. Y.;Gastroenterology,1993

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