Cell Wall-Mediated Neuronal Damage in Early Sepsis-Reference-Cited by-同舟云学术

Cell Wall-Mediated Neuronal Damage in Early Sepsis

Published:2006-07 Issue:7 Volume:74 Page:3783-3789
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Orihuela Carlos J.¹,Fillon Sophie¹,Smith-Sielicki S. Hope¹,El Kasmi Karim C.¹,Gao Geli¹,Soulis Konstantinos¹,Patil Avinash²,Murray Peter J.¹,Tuomanen Elaine I.¹

Affiliation:

1. Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale Rd., Memphis, Tennessee 38105

2. University of Tennessee Medical School, Dunlap Ave., Memphis, Tennessee 38163

Abstract

ABSTRACT Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed in the hippocampus within hours in experimental pneumococcal bacteremia. Intravascular challenge with purified bacterial cell wall recapitulated SAND. SAND persisted in PAFr −/− mice but was partially mitigated in mice lacking cell wall recognition proteins TLR2 and Nod2 and in mice overexpressing interleukin-10 (IL-10) in macrophages. Thus, cell wall drives SAND through IL-10-repressible inflammatory events. Treatment with CDP-choline ameliorated SAND, suggesting that it may be an effective adjunctive therapy to increase survival and reduce organ damage in sepsis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00022-06

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