Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection

Author:

Choi Eun-Jin1,Ren Yuping12,Chen Yu13,Liu Shengxuan13,Wu Wenzhe1,Ren Junping1,Wang Pingyuan4,Garofalo Roberto P.1567,Zhou Jia456,Bao Xiaoyong1567

Affiliation:

1. Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA

2. Department of Plastic and Cosmetic Surgery, TongJi Hospital, TongJi Medical College, Huazhong University of Science and Technology, China

3. Department of Pediatrics, TongJi Hospital, TongJi Medical College, Huazhong University of Science and Technology, China

4. Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, Texas, USA

5. Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas, USA

6. Institute of Translational Science, University of Texas Medical Branch, Galveston, Texas, USA

7. Institute for Human Infections &Immunity, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

RSV is a serious public health problem, as it is associated with bronchiolitis, pneumonia, and asthma exacerbations. Currently no effective treatment or vaccine is available, and many molecular mechanisms regarding RSV-induced lung disease are still significantly unknown. This project aims to elucidate an important and novel function of a protein, called EPAC2, in RSV replication and innate inflammatory responses. Our results should provide an important insight into the development of new pharmacologic strategies against RSV infection, thereby reducing RSV-associated morbidity and mortality.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Flight Attendant Medical Research Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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