Detecting 16S rRNA Methyltransferases in Enterobacteriaceae by Use of Arbekacin-Reference-Cited by-同舟云学术

Detecting 16S rRNA Methyltransferases in Enterobacteriaceae by Use of Arbekacin

Published:2016-01 Issue:1 Volume:54 Page:208-211
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

McGann Patrick¹,Chahine Sarah¹,Okafor Darius¹,Ong Ana C.¹,Maybank Rosslyn¹,Kwak Yoon I.¹,Wilson Kerry²,Zapor Michael³,Lesho Emil¹,Hinkle Mary¹

Affiliation:

1. Multidrug-resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

2. Infectious Diseases Service, Walter Reed National Military Medical Center, Bethesda, Maryland, USA

3. Division of Bacterial & Rickettsial Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

Abstract

ABSTRACT 16S rRNA methyltransferases confer resistance to most aminoglycosides, but discriminating their activity from that of aminoglycoside-modifying enzymes (AMEs) is challenging using phenotypic methods. We demonstrate that arbekacin, an aminoglycoside refractory to most AMEs, can rapidly detect 16S methyltransferase activity in Enterobacteriaceae with high specificity using the standard disk susceptibility test.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02642-15

Reference22 articles.

1. Aminoglycoside Antibiotics in the 21st Century

2. Aminoglycoside modifying enzymes

3. 16S Ribosomal RNA Methylation: Emerging Resistance Mechanism against Aminoglycosides

4. Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens;Matsumoto T;Clin Pharmacol,2014

5. Arbekacin Activity against Contemporary Clinical Bacteria Isolated from Patients Hospitalized with Pneumonia

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