Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor-Reference-Cited by-同舟云学术

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

LaRock Doris L.¹,Russell Raedeen¹,Johnson Anders F.²,Wilde Shyra²,LaRock Christopher N.¹³⁴^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

2. Microbiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, Georgia, USA

3. Department of Medicine, Division of Infectious Disease, Emory University School of Medicine, Atlanta, Georgia, USA

4. Antimicrobial Resistance Center, Emory University, Atlanta, Georgia, USA

Abstract

Group A Streptococcus (GAS) is the etiologic agent of numerous high-morbidity and high-mortality diseases. Infections are typically highly proinflammatory. During the invasive infection necrotizing fasciitis, this is in part due to the GAS protease SpeB directly activating interleukin-1β (IL-1β) independent of the canonical inflammasome pathway. The upper respiratory tract is the primary site for GAS colonization, infection, and transmission, but the host-pathogen interactions at this site are still largely unknown.

Funder

NIH/NIAID

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00356-20

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