BK Polyomavirus Subtypes II and IV in Hematopoietic Cell Transplant Recipients

Author:

Odegard Elizabeth A.1,Meeds Heidi L.1,Kleiboeker Steven B.2,Ziady Assem34,Sabulski Anthony34,Jodele Sonata34,Seif Alix E.56,Davies Stella M.34,Laskin Benjamin L.57,Blackard Jason T.1ORCID

Affiliation:

1. Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

2. Eurofins Viracor Laboratories, Lee’s Summit, Missouri, USA

3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

4. Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

5. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

6. Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

7. Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Abstract

Symptomatic BK polyomavirus (BKPyV) infections are common and relevant in immunocompromised patients. Here, we present full-length BKPyV genomes from samples from patients who received hematopoietic cell transplants in the United States. These individuals had non-subtype I BKPyV, as determined by amplification, next-generation sequencing, and phylogenetic analysis.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Genetics,Immunology and Microbiology (miscellaneous),Molecular Biology

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