Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses-Reference-Cited by-同舟云学术

Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses

Published:2021-01-13 Issue:3 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Berendam Stella J.¹²,Styles Tiffany M.³,Morgan-Asiedu Papa K.¹,Tenney DeAnna⁴,Kumar Amit¹,Obregon-Perko Veronica⁵,Bar Katharine J.⁶,Saunders Kevin O.¹,Santra Sampa⁷,De Paris Kristina⁸,Tomaras Georgia D.⁴,Chahroudi Ann⁵⁹^ORCID,Permar Sallie R.¹²,Amara Rama R.³,Fouda Genevieve G.¹²^ORCID

Affiliation:

1. Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA

2. Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA

3. Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA

4. Department of Surgery, School of Medicine, Duke University, Durham, North Carolina, USA

5. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

6. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

7. Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

8. Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, USA

9. Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA

Abstract

Optimal bNAb immunotherapeutics will need to mediate multiple antiviral functions against a broad range of HIV strains. Our systematic assessment of triple bNAb combinations against SHIVs will identify bNAbs with synergistic, polyfunctional antiviral activity that will inform the selection of candidate bNAbs for optimal combination designs. The identified combinations can be validated in vivo in future passive immunization studies using the SHIV challenge model.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01667-20

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