Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species-Reference-Cited by-同舟云学术

Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species

Published:2016-01 Issue:1 Volume:60 Page:703-708
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bidet Philippe¹²³,Basmaci Romain¹²³,Guglielmini Julien¹²,Doit Catherine¹²³,Jost Christelle¹²³,Birgy André¹²,Bonacorsi Stéphane¹²³

Affiliation:

1. INSERM, IAME, UMR 1137, Paris, France

2. Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, Paris, France

3. AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France

Abstract

ABSTRACT We describe the genome of a penicillinase-producing Kingella kingae strain (KWG1), the first to be isolated in continental Europe, whose bla TEM-1 gene was, for the first time in this species, found to be chromosomally inserted. The bla TEM gene is located in an integrative and conjugative element (ICE) inserted in Met-tRNA and comprising genes that encode resistance to sulfonamides, streptomycin, and tetracycline. This ICE is homologous to resistance-conferring plasmids of K. kingae and other Gram-negative bacteria.

Funder

Booster Innovation fund of Assistance Publique—Hopitaux de Paris

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02192-15

Reference22 articles.

1. Kingella Kingae Osteoarticular Infections in Young Children: Clinical Features and Contribution of a New Specific Real-time PCR Assay to the Diagnosis

2. Specific Real-Time Polymerase Chain Reaction Places Kingella kingae as the Most Common Cause of Osteoarticular Infections in Young Children

3. New Real-Time PCR-Based Method for Kingella kingae DNA Detection: Application to Samples Collected from 89 Children with Acute Arthritis