Implementation of a Vancomycin Dose-Optimization Protocol in Neonates: Impact on Vancomycin Exposure, Biological Parameters, and Clinical Outcomes-Reference-Cited by-同舟云学术

Implementation of a Vancomycin Dose-Optimization Protocol in Neonates: Impact on Vancomycin Exposure, Biological Parameters, and Clinical Outcomes

Published:2022-05-17 Issue:5 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gomez Laura¹,Boegler Diane²,Epiard Chloé²,Alin Layli²,Arata-Bardet Julie³,Caspar Yvan⁴⁵,Debillon Thierry²⁶,Stanke-Labesque Françoise¹⁷,Gautier-Veyret Elodie¹⁷^ORCID

Affiliation:

1. Laboratory of Pharmacology, Pharmacogenetics, and Toxicology, Grenoble Alpes University Hospital, La Tronche, France

2. Neonatal Intensive Care Unit, Grenoble Alpes University Hospital, La Tronche, France

3. Pediatric Infectiology, Pediatrics Department, Grenoble Alpes University Hospital, La Tronche, France

4. Laboratory of Bacteriology, Grenoble Alpes University Hospital, La Tronche, France

5. University of Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France

6. University of Grenoble Alpes, TIMC, MESP Team, La Tronche, France

7. INSERM 1300, CHU Grenoble Alpes, University of Grenoble Alpes, Grenoble, France

Abstract

Vancomycin dosing used in neonates results frequently in insufficient concentrations. A vancomycin dose-optimization protocol consisting of an individualization of loading and maintenance doses (administered during continuous infusion) through a previously validated pharmacokinetic model was implemented in our center.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02191-21

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