Identification and Characterization of Staphylococcus delphini Internalization Pathway in Nonprofessional Phagocytic Cells

Author:

Maali Yousef12ORCID,Diot Alan12,Martins-Simões Patrícia13,Bes Michele13,Bouvard Daniel45,Vandenesch François123ORCID,Verhoeven Paul O.67,Laurent Frederic123,Trouillet-Assant Sophie12

Affiliation:

1. CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France

2. Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France

3. Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, Lyon, France

4. INSERM U1209, Albert Bonniot Institute, Grenoble, France

5. Université Grenoble Alpes, Grenoble, France

6. Laboratory of Infectious Agents and Hygiene, University Hospital of Saint-Etienne, Saint-Etienne, France

7. GIMAP (Groupe Immunité Muqueuses et Agents Pathogènes) EA3064, Faculté de Médecine, Université Jean Monnet, Université de Lyon, Saint-Etienne, France

Abstract

The intracellular lifestyle of bacteria is widely acknowledged to be an important mechanism in chronic and recurring infection. Among the Staphylococcus genus, only Staphylococcus aureus and Staphylococcus pseudintermedius have been clearly identified as intracellular in nonprofessional phagocytic cells (NPPCs), for which the mechanism is mainly fibronectin-binding dependent. Here, we used bioinformatics tools to search for possible new fibronectin-binding proteins (FnBP-like) in other Staphylococcus species.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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