Translating Recent Microbiome Insights in Otitis Media into Probiotic Strategies-Reference-Cited by-同舟云学术

Translating Recent Microbiome Insights in Otitis Media into Probiotic Strategies

Published:2019-09-18 Issue:4 Volume:32 Page:
ISSN:0893-8512
Container-title:Clinical Microbiology Reviews
language:en
Short-container-title:Clin Microbiol Rev

Author:

van den Broek Marianne F. L.¹,De Boeck Ilke¹,Kiekens Filip²,Boudewyns An³,Vanderveken Olivier M.³⁴,Lebeer Sarah¹^ORCID

Affiliation:

1. Environmental Ecology and Applied Microbiology Research Group, Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium

2. Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium

3. Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium

4. Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

Abstract

The microbiota of the upper respiratory tract (URT) protects the host from bacterial pathogenic colonization by competing for adherence to epithelial cells and by immune response regulation that includes the activation of antimicrobial and (anti-)inflammatory components. However, environmental or host factors can modify the microbiota to an unstable community that predisposes the host to infection or inflammation. One of the URT diseases most often encountered in children is otitis media (OM).

Funder

Fonds Wetenschappelijk Onderzoek

Agentschap voor Innovatie door Wetenschap en Technologie

Universiteit Antwerpen

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Link

https://journals.asm.org/doi/pdf/10.1128/CMR.00010-18

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1. The microbiota of the respiratory tract: gatekeeper to respiratory health