Chlamydia -Specific IgA Secretion in the Female Reproductive Tract Induced via Per-Oral Immunization Confers Protection against Primary Chlamydia Challenge-Reference-Cited by-同舟云学术

Chlamydia -Specific IgA Secretion in the Female Reproductive Tract Induced via Per-Oral Immunization Confers Protection against Primary Chlamydia Challenge

Published:2020-12-15 Issue:1 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Shillova Nita¹,Howe Savannah E.¹²,Hyseni Besmir¹,Ridgell Deahneece¹,Fisher Derek J.¹^ORCID,Konjufca Vjollca¹^ORCID

Affiliation:

1. School of Biological Sciences, Southern Illinois University, Carbondale, Illinois, USA

2. Vaccine Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Chlamydia trachomatis is an obligate intracellular pathogen that causes sexually transmitted disease. In women, chlamydial infections may cause pelvic inflammatory disease (PID), ectopic pregnancy, and infertility. The role of antibodies in protection against a primary Chlamydia infection is unclear and was a focus of this work. Using the C. muridarum mouse infection model, we show that intestinal mucosa is infected via intranasal (i.n.) or per-oral (p.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00413-20

Reference62 articles.

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2. CDC. 2018. Sexually transmitted disease surveillance 2018. https://www.cdc.gov/std/stats18/default.htm.

3. Pelvic Inflammatory Disease

4. Microbial etiology of urban emergency department acute salpingitis: Treatment with ofloxacin

5. Risk of Sequelae afterChlamydia trachomatisGenital Infection in Women

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