Role of Hematopoietic Cells in the Maintenance of Chronic Human Torquetenovirus Plasma Viremia-Reference-Cited by-同舟云学术

Role of Hematopoietic Cells in the Maintenance of Chronic Human Torquetenovirus Plasma Viremia

Published:2010-07 Issue:13 Volume:84 Page:6891-6893
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Maggi Fabrizio¹,Focosi Daniele²,Albani Melania¹,Lanini Letizia¹,Vatteroni Maria Linda¹,Petrini Mario²,Ceccherini-Nelli Luca¹,Pistello Mauro¹,Bendinelli Mauro¹

Affiliation:

1. Virology Section and Retrovirus Centre, Department of Experimental Pathology, University of Pisa, Pisa, Italy

2. Division of Hematology, Azienda Ospedaliera Universitaria Pisana Santa Chiara, Pisa, Italy

Abstract

ABSTRACT Many aspects of the life cycle of torquetenoviruses (TTVs) are essentially unexplored. In particular, it is still a matter of speculation which cell type(s) replicates the viruses and maintains the generally high viral loads found in the blood of infected hosts. In this study, we sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in the maintenance of TTV viremia.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00273-10

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