Author:
Weber A F,Opheim K E,Koup J R,Smith A L
Abstract
A radioenzymatic assay and a "high-performance" liquid chromatographic assay for chloramphenicol were compared by using 52 patient specimens, 24 mock unknowns, and 13 quality control samples. Both methods were found to be rapid, precise, accurate, and sensitive, and either would be suitable for monitoring chloramphenicol concentrations in small volumes of serum. Linear regression analysis of serum chloramphenicol concentrations in patients receiving chloramphenicol succinate yielded a regression equation of Y = 1.04X + 0.274 (X = high-performance liquid chromatographic assay; Y = radioenzymatic assay), with a correlation coefficient of 0.971.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference8 articles.
1. Biochemical studies on chloramphenicol. I. Colorimetric methods for the determination of chloramphenicol and related aromatic nitro compounds;Glazko A. J.;Arch. Biochem.,1949
2. Chloramphenicol and the neonate-1979 view;Uetman P. S.;Clin. Perinatol.,1979
3. Rapid microbiological assay for chloramphenicol and tetracyclines;Louie T. J.;Antimicrob. Agents Chemother.,1976
4. Gas chromatographic determination and gas chromatographic-mass spectrophotometric analysis of chloramphenicol, thiamphenicol and their metabolites;Nakagawa T.;J. Chromatography,1975
5. Micro-scale method for liquid chromatographic determination of chloramphenicol in serum;Petersdorf S. H.;Clin. Chem.,1979
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