Vaccine-Associated Enhanced Respiratory Disease following Influenza Virus Infection in Ferrets Recapitulates the Model in Pigs-Reference-Cited by-同舟云学术

Vaccine-Associated Enhanced Respiratory Disease following Influenza Virus Infection in Ferrets Recapitulates the Model in Pigs

Published:2022-03-09 Issue:5 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kimble J. Brian¹,Wymore Brand Meghan¹,Kaplan Bryan S.¹,Gauger Phillip²^ORCID,Coyle Elizabeth M.³,Chilcote Katarina³,Khurana Surender³,Vincent Amy L.¹^ORCID

Affiliation:

1. Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, Iowa, USA

2. Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa, USA

3. Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, Maryland, USA

Abstract

We demonstrated the susceptibility of ferrets, a laboratory model species for human influenza A virus research, to vaccine-associated enhanced respiratory disease (VAERD) using an experimental model previously demonstrated in pigs. Ferrets developed clinical characteristics of VAERD very similar to that in pigs.

Funder

HHS | National Institutes of Health

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01725-21

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