Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide

Author:

Emini E A,Hughes J V,Perlow D S,Boger J

Abstract

Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference21 articles.

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5. Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies;Emini E. A.;J. Virol.,1982

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