Rapid Emergence of Resistance to Linezolid during Linezolid Therapy of an Enterococcus faecium Infection-Reference-Cited by-同舟云学术

Rapid Emergence of Resistance to Linezolid during Linezolid Therapy of an Enterococcus faecium Infection

Published:2006-12 Issue:12 Volume:50 Page:4217-4219
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Seedat Jamela¹,Zick Günther²,Klare Ingo³,Konstabel Carola³,Weiler Norbert²,Sahly Hany¹

Affiliation:

1. Institute for Infection Medicine, Brunswiker Str. 4

2. Department of Anaesthesiology and Intensive Care Medicine, Schwanenweg 21, University Hospital Schleswig-Holstein, Campus Kiel, D-24105 Kiel

3. Robert Koch Institute, Wernigerode Branch, Burgstr. 37, D-38855 Wernigerode, Germany

Abstract

ABSTRACT We report the emergence of linezolid resistance (MICs of 16 to 32 mg/liter) in clonally related vancomycin-susceptible and -resistant Enterococcus faecium isolates from an intensive care unit patient after 12 days of linezolid therapy. Only linezolid-susceptible isolates of the same clone were detected at 28 days after termination of linezolid therapy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00518-06

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