Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria-Reference-Cited by-同舟云学术

Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria

Published:2018-10 Issue:10 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lohy Das Jesmin¹^ORCID,Rulisa Stephen²,de Vries Peter J.³,Mens Petra F.⁴,Kaligirwa Nadine⁵,Agaba Steven⁵,Tarning Joel⁶⁷^ORCID,Karlsson Mats O.¹,Dorlo Thomas P. C.¹⁸^ORCID

Affiliation:

1. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

2. Department of Clinical Research, University of Kigali, Kigali, Rwanda

3. Tergooi Hospital, Hilversum, the Netherlands

4. Department of Medical Microbiology, Academic Medical Center, Amsterdam, the Netherlands

5. Center for Treatment and Research on AIDS, Malaria and TB (TRAC PLUS), Rwanda Biomedical Center, Kigali, Rwanda

6. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

7. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

8. Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands

Abstract

The artemisinin-based combination therapy artemether-lumefantrine is commonly used in pregnant malaria patients. However, the effect of pregnancy-related changes on exposure is unclear, and pregnancy has been associated with decreased efficacy in previous studies.

Funder

Netherlands Organisation for Scientific Research-Global Health

Netherlands Organisation for Scientific Research

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00518-18

Reference64 articles.

1. World Trade Report 2016