Deletion of U L 21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle-Reference-Cited by-同舟云学术

Deletion of U L 21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle

Published:2012-06-15 Issue:12 Volume:86 Page:7003-7007
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mbong Ekaette F.¹,Woodley Lucille¹,Frost Elizabeth¹,Baines Joel D.²,Duffy Carol¹

Affiliation:

1. Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama, USA

2. Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA

Abstract

ABSTRACT The herpes simplex virus 1 (HSV-1) U L 21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U L 21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U L 21 results in a delay early in the HSV-1 replication cycle.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00411-12

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