Identification of Novel T-Cell Epitopes on Infectious Bronchitis Virus N Protein and Development of a Multi-epitope Vaccine-Reference-Cited by-同舟云学术

Identification of Novel T-Cell Epitopes on Infectious Bronchitis Virus N Protein and Development of a Multi-epitope Vaccine

Published:2021-08-10 Issue:17 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Qin Yifeng¹,Tu Kaihang¹,Teng Qingyuan¹,Feng Delan¹,Zhao Ye¹,Zhang Guozhong¹^ORCID

Affiliation:

1. Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China

Abstract

T-cell-mediated immune responses are critical for the elimination of IBV-infected cells. To screen conserved T-cell epitopes in the IBV N protein, 40 overlapping peptides covering the entirety of the N protein were designed and synthesized.

Funder

National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00667-21

Reference56 articles.

1. Infectious Bronchitis Virus Evolution, Diagnosis and Control

2. Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

3. A Novel B-Cell Epitope of Avian Infectious Bronchitis Virus N Protein