Regulation of HPV E7 Stability by E6-Associated Protein (E6AP)

Abstract

This is the first demonstration that E6AP can directly help stabilize the HPV E7 oncoprotein, in a manner similar to that observed with HPV E6. This redefines how E6 and E7 can cooperate and potentially modulate each other’s activity and further highlights the essential role played by E6AP in the viral life cycle and malignancy.