Meningococcal Quinolone Resistance Originated from Several Commensal Neisseria Species

Author:

Chen Mingliang12,Zhang Chi1,Zhang Xi1,Chen Min1

Affiliation:

1. Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

2. Department of Microbiology, Shanghai Institutes of Preventive Medicine, Shanghai, China

Abstract

Quinolone resistance is increasing in Neisseria meningitidis , with its prevalence in China being high (>70%), but its origin remains unknown. The aim of this study was to investigate the donors of mutation-harboring gyrA alleles in N. meningitidis . A total of 198  N. meningitidis isolates and 293 commensal Neisseria isolates were collected between 2005 and 2018 in Shanghai, China. The MICs of ciprofloxacin were determined using the agar dilution method.

Funder

National Health and Family Planning Commission of the People's Republic of China

National Natural Science Foundation of China

Shanghai Municipal Health Bureau

Shanghai City Youth Science and Technology Star Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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