Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine-Reference-Cited by-同舟云学术

Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine

Published:2017-11 Issue:11 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Al Laham Nahed¹,Chavda Kalyan D.²,Cienfuegos-Gallet Astrid V.³,Kreiswirth Barry N.²,Chen Liang²

Affiliation:

1. Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al Azhar University-Gaza, Gaza Strip, Palestine

2. Public Health Research Institute TB center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

3. Línea de Epidemiología Molecular Bacteriana, Grupo de Microbiología Básica y Aplicada, Universidad de Antioquia, Medellín, Colombia

Abstract

ABSTRACT Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed bla VIM-2 is harbored by a chromosomal genomic island among three strains, while bla VIM-4 is carried by a novel plasmid in two strains.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01499-17

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