Whole-Genome Sequences of Thirteen Isolates of Borrelia burgdorferi

Author:

Schutzer Steven E.1,Fraser-Liggett Claire M.2,Casjens Sherwood R.3,Qiu Wei-Gang4,Dunn John J.5,Mongodin Emmanuel F.2,Luft Benjamin J.6

Affiliation:

1. Department of Medicine, University of Medicine and Dentistry of New Jersey—New Jersey Medical School, Newark, New Jersey 07103

2. Institute for Genome Sciences, University of Maryland, School of Medicine, Department of Microbiology and Immunology, Baltimore, Maryland 21201

3. Department of Pathology, Division of Microbiology and Immunology, University of Utah Medical School, Salt Lake City, Utah 84112

4. Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021

5. Biology Department, Brookhaven National Laboratory, Upton, New York 11793

6. Department of Medicine, Health Science Center, Stony Brook University, Stony Brook, New York 11794

Abstract

ABSTRACT Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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