Sequence specificity of the core-binding factor-Reference-Cited by-同舟云学术

Sequence specificity of the core-binding factor

Published:1993-04 Issue:4 Volume:67 Page:2408-2411
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Melnikova I N¹,Crute B E¹,Wang S¹,Speck N A¹

Affiliation:

1. Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755.

Abstract

The core-binding factor (CBF) binds the conserved core motif in mammalian type C retrovirus enhancers. We analyzed the phosphate contacts made by CBF on the Moloney murine leukemia virus enhancer by ethylation interference assay. The phosphate contacts span 9 bp centered around the consensus core site. To examine the sequence preferences for CBF binding, we employed the technique of selected and amplified binding sequence footprinting (T. K. Blackwell and H. Weintraub, Science 250:1104-1110, 1990). The consensus binding site for CBF defined by selected and amplified binding sequence footprinting is PyGPyG GTPy.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.67.4.2408-2411.1993

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