Affiliation:
1. Departments of Pediatrics and Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
Urine from patients receiving metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitromidazole] orally or per vagina were subjected to paper chromatographic fractionation and examined for anticlostridial activity. Unmodified metronidazole and several metabolites were detected. These findings indicate that the clostridial bioassay may be limited in its applicability to the study of the pharmacodynamics of metronidazole as it does not differentiate between the parent substance and some of its metabolites. Moreover, some of the latter, although they possess antibacterial activity, may not have antiprotozoan activity.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference10 articles.
1. Laboratory studies of the chemotherapeutic activity and toxicity of some nitro-heterocycles;Benazet F.;Scand. J. Infect. Dis.,1970
2. Activite de l(hydroxy-2'ethyl)-1 methy1-2-nitro-5-imidazole vis-a-vis des infections experimentales a Trichomonas vaginalis;Cosar C.;Ann. Inst. Pasteur Paris,1959
3. Metronidazole and amebiasis;Everett E. D.;Am. J. Dig. Dis.,1974
4. Cutaneous leishmaniasis treated with metronidazole;Long P. I.;J. Am. Med. Assoc.,1973
5. Bactericidal activity of five antimicrobial agents against Bacteroides fragilis;Nastro L. J.;J. Infect. Dis.,1972
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献