Effect of Bleomycin on Deoxyribonucleic Acid Synthesis in Toluene-Treated Escherichia coli Cells-Reference-Cited by-同舟云学术

Effect of Bleomycin on Deoxyribonucleic Acid Synthesis in Toluene-Treated Escherichia coli Cells

Published:1976-02 Issue:2 Volume:9 Page:239-246
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ross Steven L.¹,Moses Robb E.¹

Affiliation:

1. Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77025

Abstract

The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA polymerase I-dependent DNA synthesis increases. Bleomycin does not appear to have any effect on purified E. coli DNA polymerases I or II. Our results suggest that bleomycin causes nicking of the bacterial chromosome with subsequent DNA synthesis catalyzed by DNA polymerase I.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.9.2.239

Reference34 articles.

1. Enzymatic synthesis dexoyribonucleic acid. IX. The polymerase formed after T2 bacteriophage infection of Escherichia coli: a new enzyme;Aposhian H. V.;J. Biol. Chem.,1962

2. Ultravioletirradiation inhibition of replicative DNA synthesis in toluene-treated Escherichia coli;Bowersock R. D.;J. Biol. Chem.,1973

3. Enzymatic DNA degradation in Escherichia coli: its relationship to synthetic processes at the chromosome level;Buttin G.;Cold Spring Harbor Symp. Quant. Biol.,1968

4. Mapping of a mutation, polBlOO, affecting deoxyribonucleic acid polymerase II in Escherichia coli K-12;Campbell J. L.;J. Bacteriol.,1974

5. Isolation of an E. coli strain with a mutation affecting DNA polymerase;DeLucia P.;Nature (London) New Biol.,1969

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Production of (S)-2-chloropropionate by asymmetric reduction of 2-chloroacrylate with 2-haloacrylate reductase coupled with glucose dehydrogenase;Journal of Bioscience and Bioengineering;2008-04

2. RecBC promoted repair of bleomycin damage in Escherichia coli;Biochimie;1991-04

3. Effect of DNA polymerase inhibitors on DNA repair in intact and permeable human fibroblasts: evidence that DNA polymerases .delta. and .beta. are involved in DNA repair synthesis induced by N-methyl-N'-nitro-N-nitrosoguanidine;Biochemistry;1990-01-09

4. Bleomycin-treated DNA is specifically cleaved only by endonuclease IV in E. coli;Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression;1990-01

5. DNA repair synthesis in isolated rainbow trout liver cells;Carcinogenesis;1989